You can use (Windows Management Instrumentation) like this: Dim mos As New ManagementObjectSearcher('SELECT * FROM Win32_PhysicalMedia') For Each mo As ManagementObject In mos.Get() Dim serial As String = mo('SerialNumber').ToString() Next Although, I've read about cases in which no serial number is returned using WMI. Another way to accomplish this would be through Platform Invocation Services (PInvoke). Article includes a download in which the author implements and to extract drive information through Interop services in VB.NET. To use either of the above outlined methods you will need ADMIN rights, a utility which seems to circumvent this can be found. If your feeling adventurous the C++/Win32 is available for you to peruse. (Check out the function 'ReadPhysicalDriveInNTWithZeroRights()').

Get mother board serial numbers and CPU IDs in Visual Basic.NET Description This example shows how to use WMI to get mother board serial numbers and CPU IDs in Visual Basic.NET. Jan 29, 2019 - Get mother board serial numbers and CPU IDs in. Management Instrumentation, Visual Basic.NET, VB.NET. Computer & ' root.I assume that.